Identification of urinary proteomic profile of patients with chronic allograft nephropathy
نویسندگان
چکیده
منابع مشابه
Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods.
PURPOSE Chronic allograft nephropathy (CAN) remains the leading cause of renal graft loss after the first year following renal transplantation. This study aimed to identify novel urinary proteomic profiles, which could distinguish and predict CAN in susceptible individuals. EXPERIMENTAL DESIGN The study included 34 renal transplant patients with histologically proven CAN and 36 patients with ...
متن کاملProteomic identification of urinary biomarkers of diabetic nephropathy.
OBJECTIVE Diabetic nephropathy is a serious complication of both type 1 and type 2 diabetes, and, unless arrested, leads to end-stage renal disease. Current diagnosis consists of urine assays of microalbuminuria, which have inadequate specificity and sensitivity. RESEARCH DESIGN AND METHODS We used proteomic analyses to identify novel biomarkers of nephropathy in urine from type 2 diabetic pa...
متن کاملManagement of chronic allograft nephropathy.
Chronic renal allograft disease remains a leading cause of graft loss. Immunologic and non-immunologic risk factors are related to its development and may be present before or develop after transplantation. Histological evaluation of renal tissue has an important role in the management, especially for the evaluation of immune activity against the graft and toxicity of immunosuppressive drugs. M...
متن کاملChronic Allograft Nephropathy
Since the first successful kidney transplantation in 1954 between Identical twins, a new modality to treat patients with terminal kidney insufficiency was born. Although the results in the first decades were modest, continuous development has characterized this captivating field. A major advance was the introduction of the new immunosuppressant cyclosporine A in the early 1980s. The fundament o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alexandria Journal of Medicine
سال: 2020
ISSN: 2090-5068,2090-5076
DOI: 10.1080/20905068.2020.1749782